CompletedNot Applicable

PENS vs TENS for Hand Function in Multiple Sclerosis

Spain28 participantsStarted 2026-01-01

Plain-language summary

This randomized, parallel, single-blind clinical trial aims to compare the immediate and short-term effects of percutaneous electrical nerve stimulation (PENS) versus transcutaneous electrical nerve stimulation (TENS), applied simultaneously to the median, radial, and ulnar nerves, on hand function in people with multiple sclerosis. Participants will be assessed at baseline, immediately after the intervention, and 72 hours later. Outcomes include fine manual dexterity, gross manual dexterity, pinch strength, and tactile sensitivity.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of multiple sclerosis according to McDonald criteria. * Age between 18 and 80 years. * Clinically stable for at least 2 months before enrollment. * No recent corticosteroid treatment. * Functional ability to complete the study assessments, defined as a Nine Hole -Peg Test time of less than 300 seconds and the ability to transfer at least 1 block in the Box and Block Test. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Musculoskeletal disorders or injuries affecting the upper limb. * Implanted electrical devices. * Skin lesions or dermatological conditions at the stimulation sites. * Cognitive impairment that interferes with understanding or performing the assessments. * Recent relapse or any concomitant neurological condition that could interfere with study participation or evaluation.

What they're measuring

Fine Manual Dexterity

Timeframe: Baseline, immediately post-intervention, and 72 hours post-intervention.

Trial details

NCT IDNCT07546318

SponsorUniversidad de Burgos

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-15