Not Yet RecruitingNot Applicable

Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus

70 participantsStarted 2026-06-01

Plain-language summary

The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular risk factors (dyslipidemia, hypertension, obesity) and non-traditional disease-related risk factors (disease activity, lupus nephritis, corticosteroid dose, disease duration).

Who can participate

Age range0 Years – 18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- Children and adolescents aged under 18 years diagnosed with JSLE according to the Systemic Lupus International Collaborating Clinics ( SLICC 2012 Criteria ). Disease duration of at least 6 months. Under regular follow-up at the study institution. Exclusion Criteria: * Patients with other autoimmune or connective tissue overlap diseases (e.g., mixed connective tissue disease, juvenile dermatomyositis). Patients with congenital heart disease or known structural cardiovascular abnormalities. Patients with chronic kidney disease stage 4 or 5. Patients currently receiving lipid-lowering therapy prior to enrolment

What they're measuring

CIMT values in JSLE patients compared to age- and sex-matched healthy controls.

Timeframe: Baseline

Trial details

NCT IDNCT07545408

SponsorAssiut University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-06-01

Contact for this trial

Kerolos Atef Thabet

01211014182 keroloseatef11@gmail.com

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