Not Yet RecruitingNot Applicable

Effect of Positive End-Expiratory Pressure Titration on Venous Excess Ultrasound Score and Renal Outcomes in Patients With Acute Respiratory Distress Syndrome

40 participantsStarted 2026-04-12

Plain-language summary

This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS to assess the effect of different levels of PEEP titration on VExUS score and renal outcomes in patients with Acute Respiratory Distress Syndrome.

Who can participate

Age range18 Years – 18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 years. * Diagnosis of ARDS according to the Berlin criteria. * Invasive mechanical ventilation ≥24 hours. * Requirement of PEEP ≥5 cmH₂O. Exclusion Criteria: * Known end-stage renal disease on chronic dialysis. * History of renal transplantation. * Pregnancy. * Known severe tricuspid regurgitation. * Chronic liver disease with portal hypertension. * Poor ultrasound window precluding adequate venous Doppler assessment.

What they're measuring

VExUS score

Timeframe: 3 days

Development of acute kidney injury (AKI)

Timeframe: 3 days

Trial details

NCT IDNCT07545252

SponsorFayoum University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-09-20

Contact for this trial

Hager R. Elsofey, MBBCh

+201153153624 hra13@fayoum.edu.eg

View on ClinicalTrials.gov More Acute Respiratory Distress Syndrome (ARDS) trials