Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark… (NCT07544576) | Clinical Trial Compass
By InvitationPhase 4
Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance
United States140 participantsStarted 2025-12-12
Plain-language summary
The purpose of this study is to determine whether a lower dose of corticosteroid injection with ultrasound-guidance for the treatment of knee osteoarthritis can be as effective as a higher dose that is landmark-guided. With landmark-guided dosing, it may be reasonable to use a higher amount of corticosteroid in order to ensure a sufficient amount of the medication is administered, however these injections carry the risk of side effects. Alternatively, with the use of ultrasound, it may be reasonable to use less corticosteroid, possibly decreasing the risk of side effects and increasing patient satisfaction.
Who can participate
Age range
50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Subjects who have already been evaluated within at least one of the 4 study clinics with any of the 3 providers who will be administering the treatment
* Males or females age 50 and older
* Already had completion of imaging of the affected knee(s) via radiography and/or MRI
* Imaging demonstrates osteoarthritis of any severity
* Diagnosis of primary osteoarthritis of one or both knees
* One or more symptoms associated with the osteoarthritis of at least one knee
* Patients able to provide informed consent in English and/or Spanish
Exclusion Criteria:
* Skin infection at or near area of injection site
* Recent fracture of the same knee joint within past 6 months
* Uncontrolled bleeding disorder
* Intra-articular corticosteroid injection within past 3 months
* Intra-articular HA injection within the past 3 months
* Intra-articular PRP injection within the past 3 months
* Presence of prosthetic knee joint in symptomatic knee
* Inability to report symptoms due to cognitive impairment
* Complete inability to ambulate, even with assistive device
* Any person who is pregnant or less than 1 year post-menopause
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.