CompletedNot Applicable

Clinical Impact of Different Crystalloid Solution on Early Biomarkers of Kidney Injury After Lumbar Fusion Surgery in Elderly Patients

China174 participantsStarted 2023-09-01

Plain-language summary

This study aims to compare the effects of sodium acetate Ringer's solution versus sodium lactate Ringer's solution on early postoperative renal function indicators, renal injury biomarkers, and acute kidney injury (AKI) in elderly patients undergoing lumbar fusion surgery.

Who can participate

Age range65 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age 65-80 years * planned lumbar fusion surgery * ability to provide informed consent Exclusion Criteria: * severe pre-existing cardiac, hepatic, or renal dysfunction * known allergy to study fluids * use of nephrotoxic drugs within 24 h before surgery * emergency surgery * severe psychiatric disorders or impaired consciousness * intraoperative blood loss \>1000 mL or requirement for blood transfusion * presence of malignancy

What they're measuring

Urinary neutrophil gelatinase-associated lipocalin (uNGAL)

Timeframe: Postoperative 6, 12, and 24 hours

Trial details

NCT IDNCT07542353

SponsorXianping Wu

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2024-06-19

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