Active — Not RecruitingPhase 1

Effect of Rosmarinus Officinalis Extract on Oxidative Stress and Inflammatory Biomarkers in Patients With Type 2 Diabetes(T2DM)

Mexico40 participantsStarted 2025-09-20

Plain-language summary

This study will evaluate the effects of Rosmarinus officinalis (rosemary) extract on oxidative stress and inflammation in patients with type 2 diabetes. Participants will be randomly assigned to receive either rosemary extract or a placebo for 12 weeks. The study aims to determine whether rosemary extract can improve health markers related to oxidative stress, inflammation, and metabolic function.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Confirmed diagnosis of T2DM
✓. Older adults over the age of 18.
✓. Signed Informed Consent (Annex 1)
✓. Clinical stability or absence of acute complications associated with diabetes or another disease at the time of the study.
✓. Absence of other associated diseases except Obesity and/or Hypertension
✓. Glomerular filtration rate greater than or equal to 60ml/min/1.73m2 according to the CKD-EPI 2021 formula

Exclusion criteria

✕. Allergy or hypersensitivity to any of the components of Rosemary.
✕. Pregnant or breastfeeding women.
✕. Patients who are taking other supplements or medications that may interfere with the study results. (antioxidants)

What they're measuring

Change in levels of Glutathione

Timeframe: .Baseline (Day 0) and Month 3

Change in serum levels of Malondialdehyde

Timeframe: Baseline (Day 0), Month 1, Month 2, Month 3

Change in antioxidant enzyme activity of Superoxide Dismutase

Timeframe: Baseline (Day 0) and Month 3

Trial details

NCT IDNCT07541729

SponsorUniversidad Autonoma de Zacatecas

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-01

View on ClinicalTrials.gov More Type 2 Diabetes Mellitus (T2DM) trials