Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow (NCT07540481) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow
Turkey (Türkiye)61 participantsStarted 2026-04-15
Plain-language summary
This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia.
ONSD will be measured noninvasively using transorbital ultrasonography, and carotid Doppler parameters will be assessed at two time points: after endotracheal intubation and approximately 5 minutes after catheterization. The primary objective is to assess short-term changes in ONSD following catheterization.
Secondary objectives include evaluating changes in carotid Doppler measurements and their relationship with ONSD, as well as associations with physiological parameters such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years
* Patients undergoing surgery under general anesthesia
* Patients requiring internal jugular vein catheterization as part of routine clinical care
* Ability to obtain optic nerve sheath diameter measurements using transorbital ultrasonography
* Provision of informed consent
Exclusion Criteria:
* Known intracranial pathology affecting intracranial pressure
* Ocular conditions preventing accurate ultrasonographic measurement (e.g., orbital trauma, ocular surgery, infection)
* Hemodynamic instability
* Contraindication to internal jugular vein catheterization
* Inability to obtain adequate ultrasound images
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Optic Nerve Sheath Diameter (mm) Following Internal Jugular Vein Catheterization
Timeframe: Baseline (immediately after endotracheal intubation) and 5 minutes after internal jugular vein catheterization
Trial details
NCT IDNCT07540481
SponsorKanuni Sultan Suleyman Training and Research Hospital