The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis

Inclusion Criteria: * Clinically diagnosed with primary angle-closure glaucoma (PACG) * Aged ≥ 50 years, no gender restriction * Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity * Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology * Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery Exclusion Criteria: * Secondary glaucoma * History of previous intraocular surgery * Systemic diseases that can cause abnormal ocular zonules * Other severe ocular diseases * Long-term use of medications affecting connective tissue metabolism