Effectiveness of Dexamethasone Injection for Reducing Pain After Third Molar Surgery (NCT07538375) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Effectiveness of Dexamethasone Injection for Reducing Pain After Third Molar Surgery
Pakistan70 participantsStarted 2025-12-01
Plain-language summary
This randomized clinical trial aims to evaluate the effectiveness of dexamethasone injection in reducing postoperative pain after surgical removal of impacted mandibular third molars. Patients are divided into two groups: one receiving standard local anesthesia, and the other receiving an additional dexamethasone injection postoperatively. Pain levels are assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours after surgery. The study is conducted at 28 Military Dental Centre, Lahore.
Who can participate
Age range
20 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 20 to 40 years
* Patients with at least one impacted mandibular third molar (Class A or B, Class I or II) including mesioangular, horizontal, vertical, or distoangular impactions according to Pell and Gregory classification confirmed by panoramic radiograph
* Patients with no systemic disease (e.g., diabetes mellitus, hypertension, ischemic heart disease)
* Patients of either gender
Exclusion Criteria:
* Patients who have used analgesics or related drugs within 15 days prior to surgery
* Pregnant patients
* Patients with known allergy to corticosteroids
* Patients with tooth associated with cyst, tumor, or trauma
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postoperative pain intensity
Timeframe: 24 hours, 48 hours, and 72 hours postoperatively