Triage and Recognition of Acute Aortic Dissection in Chest Pain by Electrocardiogram-Artificial I… (NCT07536932) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Triage and Recognition of Acute Aortic Dissection in Chest Pain by Electrocardiogram-Artificial Intelligence
10,000 participantsStarted 2026-04
Plain-language summary
The goal of this prospective multicenter observational study is to learn whether an artificial intelligence model based on electrocardiograms (ECGs) can help diagnose acute type A aortic dissection (TAAD) in adults who come to the emergency department with chest pain or related symptoms. The main question it aims to answer is:
Can the AI-ECG model accurately distinguish TAAD from other causes of chest pain in a real-world emergency setting? Researchers will compare the AI model's ECG-based predictions with the final diagnosis confirmed by computed tomographic angiography (CTA), which is the reference standard. Participants will undergo routine emergency ECG testing and subsequent diagnostic evaluation as part of standard care. Clinical and ECG data will be collected from five tertiary hospitals, and the model's diagnostic performance will be assessed across centers.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male or female emergency department patients aged 18-80 years;
* Clear presentation of chest pain or related chest/back pain;
* Completion of standard 12-lead electrocardiography (ECG) within 24 hours after onset of chest pain;
* ECG signal quality meeting the following criteria: QRS amplitude ≥ 0.1 mV and noise proportion \< 20%;
* Availability of subsequent diagnostic workup confirming whether the patient had acute type A aortic dissection (TAAD) or another definitive diagnosis.
Exclusion Criteria:
* Poor-quality ECG recordings, defined as missing leads in ≥ 3 leads or severe baseline instability;
* Indeterminate final diagnosis;
* History of prior surgery involving the aortic valve, aortic root, or ascending aorta.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing an AI tool that reads ECGs to detect aortic dissection — if I came to the emergency room with chest pain, would this AI system currently be available to help diagnose me, or is it still being studied?
2Since this study is in a diagnostic phase and hasn't started recruiting yet, what are the current standard methods my care team would use to distinguish aortic dissection from other causes of chest pain, and how reliable are those compared to what this AI is trying to achieve?
3If this trial eventually shows the AI-ECG model works well, how might that change how quickly someone like me could get diagnosed and treated in an emergency situation?
4Given that this study is not yet recruiting, is there anything about my specific situation — like my type of chest pain symptoms or risk factors — that might make me a good or poor candidate to discuss for future enrollment once it opens?
5Are there other ongoing or available studies or diagnostic approaches I should know about right now, since this trial hasn't started yet and I may need answers sooner?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Diagnostic performance of the AI-based electrocardiogram model for acute type A aortic dissection
Timeframe: From emergency department presentation to completion of CTA and final diagnostic confirmation during the index visit, up to 24 hours