RecruitingNot Applicable

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

Chile30 participantsStarted 2023-06-01

Plain-language summary

The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is: Is the JAK1/2 pathway overactivated in periodontitis compared to health? Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults * Sistemically healthy Exclusion Criteria: * Active Maliganancy * History of radiation to the head-neck region * Chemotherapy or radiation within the last 5 years * History of hepatitis B/C or HIV infection * Autoimmune diseases * Diagnosis of diabetes * Pregnancy or lactation * More than 3 hospitalizations over the last 3 years * Use of systemic antibiotics over the last 3 months * Use of systemic corticosteroids or immunosuppressants over the last 3 months * Use of cytokine therapy over the last 3 months * Use of large doses of pre/probiotic supplements over the last 3 months * Smoke more than 10 cigarettes per day

What they're measuring

JAK1/2 pathway activation in gingival tissues

Timeframe: Day 1

Trial details

NCT IDNCT07536204

SponsorUniversity of Chile

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-03-31

Contact for this trial

Nicolas Dutzan, DDS, PhD

+56934037995 ndutzan@uchile.cl

View on ClinicalTrials.gov More Periodontitis trials