Not Yet RecruitingNot Applicable

Prophylactic Anti-epileptic Regimen in Traumatic Brain Injury

70 participantsStarted 2026-05-01

Plain-language summary

To evaluate the effectiveness and safety of anti-epileptic drugs in the prevention of early and late post-traumatic seizures among patients with trauma brain injury

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Patients with a confirmed diagnosis of traumatic brain injury (clinical and/or radiological), including both surgical and conservative management
✓. Admission within 24 hours of injury
✓. Eligible for antiepileptic prophylaxis according to clinical guidelines
✓. Written informed consent obtained.

Exclusion criteria

✕. Pre-existing epilepsy or seizure disorder.
✕. Seizure episode before or during admission unrelated to acute TBI.
✕. Prior use of antiepileptic drugs before admission.
✕. Severe renal impairment (creatinine clearance \<30 mL/min).
✕. Hepatic failure.
✕. Pregnancy or lactation.
✕. Known hypersensitivity to antiepileptic drugs

What they're measuring

Incidence of seizure

Timeframe: 3 months

Trial details

NCT IDNCT07535736

SponsorAssiut University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-05-30

Contact for this trial

Geabel Al-Qubli, Master candidate

01034732278 geabelalqubli1996@gmail.com

View on ClinicalTrials.gov More Antiepileptic Efficacy and Safety trials