Active — Not RecruitingNot Applicable

Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis

Egypt36 participantsStarted 2026-03-01

Plain-language summary

The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.

Who can participate

Age range20 Years – 60 Years

SexALL

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Inclusion criteria

✓. Single rooted teeth with pulp necrosis and apical periodontitis.
✓. The age ranges from 20 to 60 years.

Exclusion criteria

✕. Patient receiving antibiotic treatment within the preceding 3 months.
✕. Patient reporting systemic disease.
✕. Teeth that can not be isolated with rubber dam.
✕. Teeth with periodontal pockets deeper than 3 mm.

What they're measuring

Relief of signs and symptoms of apical periodontitis

Timeframe: 1 Week

Decrease in bacterial count within the root canal.

Timeframe: 1 week

Decrease in interleukin TNF-alpha, IL-1 Beta and PG-E2 in the periapical tissues

Timeframe: 1 week

Trial details

NCT IDNCT07534943

SponsorMansoura University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-01

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