The study has 2 groups, one each focusing on co-administration of elecoglipron and atorvastatin or rosuvastatin to assess the pharmacokinetics (PK) of atorvastatin in healthy participants.
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Area under concentration-time curve from time 0 to infinity (AUCinf) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
Area under concentration-curve from time 0 to the last quantifiable concentration (AUClast) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
Maximum observed drug concentration (Cmax) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
AUCinf of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
AUClast of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
Cmax of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
Ratio of Atorvastatin (Atorvastatin + elecoglipron) to Atorvastatin (alone) based on AUCinf (R AUCinf) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
Ratio of Atorvastatin (Atorvastatin + elecoglipron) to Atorvastatin (alone) based on AUClast (R AUClast) of atorvastatin
AstraZeneca Clinical Study Information Center
Timeframe: Group 1: Day 1 to Day 71
Ratio of Atorvastatin (Atorvastatin + elecoglipron) to Atorvastatin (alone) based on Cmax (R Cmax) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
Terminal elimination half-life (t1/2λz) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
Terminal rate constant (λz) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
Time to reach maximum observed concentration (tmax) of atorvastatin
Timeframe: Group 1: Day 1 to Day 71
Ratio of Rosuvastatin (Rosuvastatin + elecoglipron) to Rosuvastatin (alone) based on AUCinf (R AUCinf) of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
Ratio of Rosuvastatin (Rosuvastatin + elecoglipron) to Rosuvastatin (alone) based on AUClast (R AUClast) of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
Ratio of Rosuvastatin (Rosuvastatin + elecoglipron) to Rosuvastatin (alone) based on Cmax (R Cmax) of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
t1/2λz of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
λz of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76
tmax of rosuvastatin
Timeframe: Group 2: Day 1 to Day 76