A Phase 1 Study of JADE201 in Participants With Rheumatoid Arthritis (NCT07533955) | Clinical Trial Compass
RecruitingPhase 1
A Phase 1 Study of JADE201 in Participants With Rheumatoid Arthritis
Moldova, Ukraine36 participantsStarted 2026-05-19
Plain-language summary
This is a Phase 1, first in human study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single ascending doses of JADE201 compared to placebo in participants with Rheumatoid Arthritis
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Male and female participants 18-70 years of age, inclusive.
. A body weight between 50-100 kg and a body mass index (BMI) between 18-32 kg/m2 (all inclusive) at screening.
. Confirmed diagnosis of RA according to 2010 ACR/EULAR criteria
. Willing and able to comply with the inpatient stay at the site, scheduled visits, treatment plans, laboratory tests, and other study procedures specified in the protocol.
. Willing and able to comply with contraceptive and lifestyle requirements specified in the protocol.
Exclusion criteria
. With the exception of RA, known history of clinically significant disease
. Diagnosis or symptoms suggestive of any systemic autoimmune or inflammatory condition other than RA
. positive serology for Hep A, Hep B, or Hep C virus
. Positive, indeterminate, or invalid test of TB
. Current tobacco users who smoke \>5 cigarettes per day or equivalent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Safety and Tolerability of Single Ascending Doses of JADE201 in participants with Rheumatoid Arthritis