Vascular Complications After Kidney Transplantation (NCT07531966) | Clinical Trial Compass
RecruitingNot Applicable
Vascular Complications After Kidney Transplantation
Denmark60 participantsStarted 2026-04-01
Plain-language summary
* To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients in Denmark are evaluated according to uniform, well-defined clinical criteria.
* To investigate the efficacy and safety of catheter-based balloon treatment (percutaneous transluminal angioplasty, PTA) for these vascular complications, of which transplant renal artery stenosis is by far the most common.
* To assess whether novel imaging and functional diagnostic methods can predict treatment response.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Graft dysfunction, defined by at least one of the following:
✓. Persistent resistant hypertension for more than 6 weeks after kidney transplantation, defined as:
✓. CT or MR angiography demonstrating a lumen reduction ≥50%.
✓. Doppler ultrasound showing:
✓. Peak systolic velocity in the renal artery ≥200 cm/s and a renal renal ratio (velocity at stenosis / velocity in distal artery) \>4.
✓. Acceleration time \>70 ms in intrarenal arteries.
✓. Stenosis ≥70%.
✓. Stenosis 50-69% if at least one of the following criteria is met: