Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy (NCT07531147) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy
Turkey (Türkiye)100 participantsStarted 2026-04
Plain-language summary
Researchers will compare oral flurbiprofen (%0.25) spray and ice cream to a placebo (a look-alike substance that contains no drug) to see if oral flurbiprofen (%0.25) spray and ice cream works to effect post-thyroidectomy throat pain and voice quality.
Participants will:
* Receive 1 puff of oral flurbiprofen (0.25%) spray or 105 ml of ice cream or 1 puff of oral spray prepared with drinking water (placebo) at 5 hours postoperatively according to randomization result
* Undergo voice analysis using Praat voice analysis (University of Amsterdam) at 6 hours postoperatively
* Undergo a visual analog scale for analgesia status at 6 hours postoperatively
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* No history of neck surgery
* Age between 18-85 years
* Undergoing thyroidectomy
* Agreeing to participate in the study
* Operation duration between 60-120 minutes
Exclusion Criteria:
* History of neck surgery
* History of radiotherapy to the head and neck region
* Pre-operative or post-operative vocal cord paralysis
* Pre-operative phonetic disorder
* Pre-operative laryngeal pathology
* Being under 18 years of age
* Refusal to participate in the study
* Smoking
* Flurbiprofen allergy
* Lactose intolerance
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility of flurbiprofen (0.25%) spray and ice cream on voice quality
Timeframe: From enrollment to the postoperative sixth hour.
2
Feasibility of flurbiprofen (0.25%) spray and ice cream on pain palliation
Timeframe: From enrollment to the postoperative sixth hour.