Impact of Sodium Profiling During Haemodialysis on Haemodynamic Tolerance and Sonographic Extrava… (NCT07529990) | Clinical Trial Compass
CompletedNot Applicable
Impact of Sodium Profiling During Haemodialysis on Haemodynamic Tolerance and Sonographic Extravascular Lung Water in Shocked Patients With Acute Kidney Injury
Egypt120 participantsStarted 2024-01-01
Plain-language summary
A study conducted to evaluate the effects of sodium profiling haemodialysis compared with conventional haemodialysis on hemodynamic tolerance and extravascular lung water in critically ill patients with AKI and shock.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* • Adult Patients (18 years or older) who are admitted in ICU.
* AKI (either de novo or superimposed on CKD) as defined by (KDIGO 2023) criteria: an increase in serum creatinine (SCr) by ≥0.3 mg/dL within 48 hours, an increase in SCr to ≥1.5 times baseline within the prior 7 days, or a urine output of \<0.5 mL/kg/h for 6 hours.
* Hemodynamic instability and they need vasopressor to maintain their mean blood pressure above 65 mmHg for ≥1-2 h before initiation of HD.
* Indicated for intermittent acute hemodialysis (IHD) per treating team (e.g., refractory hyperkalemia, severe acidosis, uremic complications, or fluid overload).
Exclusion Criteria:
* • Patients with hemodynamic instability who are not responsive to vasopressors and not candidate for intermittent hemodialysis.
* ESRD on regular HD.
* Patient judged unsafe for IHD as Severe uncontrolled arrhythmia, active myocardial ischemia active intracranial pathology at risk from osmotic/sodium shifts.
* Severe dysnatremia: serum Na ≤125 or ≥150 mmol/L.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at sodium profiling during hemodialysis in patients who were both in shock and had acute kidney injury — does my situation match that profile closely enough for the findings to be relevant to my care?
2The trial measured blood pressure changes and vasopressor needs during dialysis sessions, so what do the results suggest about whether sodium profiling could help keep my blood pressure more stable if I need dialysis?
3Since the trial used lung ultrasound scores and IVC measurements to track fluid in the lungs and how the heart is handling fluid shifts, would my doctor consider using those same monitoring tools during my dialysis to watch for those risks?
4This was a completed trial listed as Phase NA, which often means it was more of an observational or feasibility study — does that mean the evidence is strong enough to change how my dialysis would actually be managed, or is it still considered preliminary?
5Are there standard dialysis approaches already being used for shocked patients with acute kidney injury that my care team would weigh against the sodium profiling technique studied here before deciding what's best for me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean Arterial Pressure (MAP) changes during the session