Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardio… (NCT07526701) | Clinical Trial Compass
CompletedNot Applicable
Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation
China36 participantsStarted 2024-11-01
Plain-language summary
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly anticoagulation strategies. This study aimed to evaluate the safety and feasibility of early 0.23-T MRI examination in ECPR patients. The investigators further assessed the image quality of the 0.23-T MRI and investigated the incidence and patterns of ABI, as well as their associations with neurological outcomes. This prospective observational study was conducted in the emergency intensive care unit (EICU) of Beijing Chaoyang Hospital, a high-volume ECPR center. The primary outcome was the feasibility of performing 0.23-T MRI in patients undergoing ECPR, defined as successful completion of the examination without serious adverse events (AEs).
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.
Exclusion Criteria:
* age \< 18 years
* unwitnessed cardiac arrest
* pregnancy
* contraindications to MRI (except ECPR, for which safety with 0.23-T MRI has been proved)
* physical dimensions exceeding scanner limits
* refusal of consent by the family
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was specifically studying people on ECPR — a very intensive form of life support after cardiac arrest — so how does that affect whether the findings from this study are relevant to my or my loved one's situation?
2The trial looked at whether a low-field 0.23-Tesla MRI scanner could be safely used on patients connected to ECPR equipment — what does it mean for brain injury care if this type of bedside MRI turns out to be feasible, and could it change how doctors monitor brain damage in our case?
3Since this trial is already completed and was measuring feasibility rather than treatment benefit, does that mean the results are more about whether the scan is safe to do near ECPR machines, and not yet about whether it leads to better outcomes for patients?
4Are there any published results from this study that you've seen, and if so, do they suggest low-field MRI is ready to be used routinely for patients on ECPR at this hospital or others we might consider?
5Given that this was a feasibility study with no specific treatment phase, what would be the next step in research or in standard care that would tell us whether this kind of imaging actually helps doctors make better decisions for patients with acute brain injury after cardiac arrest?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility of 0.23-T MRI examination
Timeframe: From the initiation of the MRI scan until 6 hours after its completion.