Reducing Blood Loss During Myomectomy:Uterine Artery Ligation Vs Pericervical Tourniquet (NCT07526311) | Clinical Trial Compass
RecruitingNot Applicable
Reducing Blood Loss During Myomectomy:Uterine Artery Ligation Vs Pericervical Tourniquet
Egypt40 participantsStarted 2026-04-10
Plain-language summary
The goal of this clinical trial is to compare two surgical techniques for reducing blood loss during transabdominal myomectomy in women with symptomatic uterine fibroids. The main question it aims to answer is whether bilateral uterine artery ligation reduces intraoperative blood loss more effectively than pericervical mechanical tourniquet application, without increasing operative complications. Researchers will compare bilateral uterine artery ligation with pericervical mechanical tourniquet application during open myomectomy to evaluate blood loss and surgical safety. Participants will undergo elective transabdominal myomectomy and will be randomly assigned to one of the two vascular control techniques before myoma enucleation.
Who can participate
Age range
25 Years – 48 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* Inclusion Criteria:
* Female participants aged 25 to 48 years
* Body mass index less than 35 kg/m²
* Symptomatic uterine myomas requiring surgical treatment
* Intramural myomas classified as FIGO types 3 to 6
* Diagnosis confirmed by transvaginal ultrasound and/or magnetic resonance imaging
* Maximum diameter of the largest myoma 20 cm or less
* Scheduled for elective transabdominal myomectomy
* Able and willing to provide written informed consent
* Exclusion Criteria:
* Submucosal, intracavitary, pedunculated subserosal, cervical, or adnexal myomas
* FIGO types 0, 1, 2, 7, or 8 myomas
* History of pelvic inflammatory disease or peritonitis
* Previous abdominal or pelvic surgery for non-obstetric causes
* Previous uterine surgery
* Use of hormonal therapy within the previous 3 months
* Known bleeding disorder
* Use of anticoagulant or antiplatelet therapy
* Preoperative hemoglobin less than 10 g/dL
* Body mass index 35 kg/m² or greater
* Intraoperative conversion from myomectomy to hysterectomy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Estimated blood loss
Timeframe: During surgery and until drain removal on the second postoperative day