This single-center randomized interventional study evaluated the biological effects of two perioperative oxygen strategies in adults undergoing elective laparoscopic lower abdominal surgery under standardized general anesthesia. Participants were assigned to receive either normoxia (FiO2 0.35) or hyperoxia (FiO2 0.80) after intubation and throughout the intraoperative period. The study assessed perioperative changes in circulating biomarkers related to pulmonary epithelial stress, endothelial glycocalyx injury, oxidative stress, and inflammation, together with blood gas and hemodynamic parameters. The study was completed before registration and is being registered retrospectively.
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Concentration of syndecan-1
Timeframe: 10 minutes after establishment of assigned oxygen fraction and immediately after surgery/post-extubation
Concentration of sialic acid
Timeframe: 10 minutes after establishment of assigned oxygen fraction and immediately after surgery/post-extubation
Concentration of surfactant protein-A
Timeframe: 10 minutes after establishment of assigned oxygen fraction and immediately after surgery/post-extubation
Concentration of ischemia-modified albumin
Timeframe: 10 minutes after establishment of assigned oxygen fraction and immediately after surgery/post-extubation
Concentration of TNF-alpha
Timeframe: 10 minutes after establishment of assigned oxygen fraction and immediately after surgery/post-extubation
Concentration of total protein
Timeframe: 10 minutes after establishment of assigned oxygen fraction and immediately after surgery/post-extubation