This study aims to compare the efficacy and safety of two antibiotic combinations (Colistin + Meropenem) vs (Imipenem/cilastatin+ Tigecycline) in the treatment of adults with MDR gram-negative infections.
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Efficacy of Treatment (Laboratory Investigation): Complete blood picture (CBC)
Timeframe: on day 1 , 3 , 5 , 7 , 9 , 11 ,13 ,15 , 17 , 19 , 21 , 23 , 25 , 27 , 29
Efficacy of treatment, (Laboratory Investigation): CRP
Timeframe: on day 3 , 6 , 9 , 12 , 15 , 18 , 21 , 24 , 27 , 30
Efficacy of treatment, Bacteriology test (culture)
Timeframe: on day 4 , 11 , 18 , 25
Efficacy parameters, Symptoms
Timeframe: on day 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30
Emergent adverse event by BUN (mg/dl) , Sr.Cr (mg/dl) and uric acid (mg/dl)
Timeframe: on day 1,3,5,7,9,11,13,15,17,19,21,23,25,27,29
Efficacy of treatment, (Laboratory Investigation): PCT
Timeframe: on day 3 , 7 , 11 , 15 , 19 , 23 , 27
Emergent adverse event by ALT and AST
Timeframe: on day 1,3,5,7,9,11,13,15,17,19,21,23,25,27,29