This prospective observational study evaluated the association of prehospital endotracheal intubation (ETI) status with return of spontaneous circulation (ROSC), 28-day survival, and favorable neurological outcome in adult patients with out-of-hospital cardiac arrest (OHCA) transported to the emergency department (ED) by emergency medical services (EMS). In addition, the study investigated the causes of failed ETI attempts and examined other clinical factors associated with 28-day survival, including bystander cardiopulmonary resuscitation (CPR), initial cardiac rhythm, blood gas parameters, and prehospital airway management strategy.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years
* Out-of-hospital cardiac arrest (OHCA)
* Transport to the emergency department by emergency medical services (EMS)
* Initiated resuscitation/advanced cardiovascular life support (ACLS) by EMS
* Enrollment period between July 1, 2025, and December 31, 2025
Exclusion Criteria:
* Age \<18 years
* In-hospital cardiac arrest
* Cardiac arrest due to major trauma, drowning, drug overdose, or known terminal illness
* Tracheostomy present
* Missing data on primary outcomes or admission laboratory parameters
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial studied 28-day survival rates after out-of-hospital cardiac arrest — can you tell me what the results showed, and whether endotracheal intubation performed by paramedics before hospital arrival actually improved survival compared to other airway approaches?
2Since this trial is now completed, has the data been published anywhere, and does it change how your team currently manages airway during cardiac arrest resuscitation in the field?
3The trial focused specifically on prehospital airway management during cardiac arrest — how does your local EMS system currently handle intubation during resuscitation, and is it consistent with what this study found?
4Are there other completed or ongoing trials comparing endotracheal intubation to alternatives like supraglottic airways during cardiac arrest that I should know about when thinking through the best evidence on this topic?
5If a family member of mine suffered an out-of-hospital cardiac arrest, would the findings from this trial influence which airway technique the responding team would use, and is there anything we can do ahead of time to make sure responders follow the most up-to-date evidence?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
28 day-survival rate
Timeframe: At 28 days after ACLS initiation following OHCA.