Effect of Graft Type on Knee Muscle Strength After ACL Reconstruction (NCT07523854) | Clinical Trial Compass
RecruitingNot Applicable
Effect of Graft Type on Knee Muscle Strength After ACL Reconstruction
Turkey (Türkiye)80 participantsStarted 2026-01-23
Plain-language summary
This prospective observational study will compare recovery after anterior cruciate ligament reconstruction using quadriceps tendon autograft or hamstring tendon autograft. The main goal is to examine differences in knee muscle strength recovery during the early and mid-term postoperative period. Participants aged 13 to 45 years who undergo unilateral ACL reconstruction and meet the eligibility criteria will be followed at Hacettepe University. Knee extensor and flexor strength will be assessed using isometric testing at postoperative weeks 4, 8, and 12 and month 6, and with isokinetic concentric testing at months 3 and 6. Functional outcomes and kinesiophobia will also be evaluated at month 6 using IKDC, KOOS, and the Tampa Scale for Kinesiophobia. All participants will receive the same standard postoperative rehabilitation program under physiotherapist supervision. The study aims to clarify whether graft type is associated with different patterns of muscle strength recovery and functional improvement after ACL reconstruction
Who can participate
Age range
13 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 13 to 45 years
* Undergoing anterior cruciate ligament reconstruction with either hamstring tendon autograft or quadriceps tendon autograft
* Unilateral anterior cruciate ligament injury
* Complete ACL tear with accompanying minimal collateral ligament injury and first-degree meniscal tear
* Tegner Activity Score of 5 or higher
* Willingness to participate in the study
Exclusion Criteria:
* Anterior cruciate ligament reconstruction with patellar tendon autograft or allograft
* Revision surgery
* Systemic or neurological disease
* Multiple ligament injuries
* Grade III lateral or medial collateral ligament tear or significant articular cartilage lesion
* Failure to regularly attend the rehabilitation program during the first 3 postoperative months
* History of lower extremity injury in the contralateral limb within the last 12 months
* Hypertension, cardiovascular disease, peripheral vascular disease, history of deep vein thrombosis, neurological disease, systemic inflammation, diabetes, cancer, or obesity
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Isometric Quadriceps Muscle Strengt
Timeframe: Postoperative weeks 4, 8, and 12, and month 6
2
Isometric Hamstring Muscle Strength
Timeframe: Postoperative weeks 4, 8, and 12, and month 6