Dysbiosis of Methanogenic Archaea and Nanoarchaea in the Oral Microbiome

Inclusion Criteria: Case selection criteria: Cases are defined as subjects with oral health vulnerability * Men or women aged 60 years or older * and/or immunocompromised individuals without periodontal disease (gingivitis, periodontitis, and peri-implantitis) clinically diagnosed by the dentist during the consultation. * Patients who have received information about the study and have not expressed objection * Patients who are beneficiaries or eligible for a social security program Control group selection criteria Controls are defined as subjects without oral health vulnerability • Men and women under 60 years of age without periodontal disease (gingivitis, periodontitis, and peri-implantitis) clinically diagnosed by the dentist during the consultation. The clinical examination allows for the diagnosis of the absence or presence of periodontal disease, with particular attention to: bleeding on probing, the depth of periodontal pocket(s), tooth mobility, bone destruction in furcation areas, and the assessment of radiographic bone level taking age into account. Exclusion Criteria: * Patients who are currently excluded from another research protocol at the time the informed consent form is collected. * Subjects covered by Articles L1121-5 through L1121-8 of the Public Health Code (minors, adults under guardianship or conservatorship, patients deprived of their liberty, pregnant or breastfeeding women), * Men and women with periodontal disease (gingivitis, periodontitis, an…