Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Di… (NCT07521566) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Different Methods
Turkey (Türkiye)48 participantsStarted 2025-09-19
Plain-language summary
This randomized controlled clinical study aimed to evaluate the effectiveness of two different de-epithelialization techniques-extraoral scalpel and intraoral radiofrequency (RF)-used in the preparation of de-epithelialized connective tissue grafts (De-CTG) for the treatment of gingival recession. A total of 48 patients were randomly assigned into two groups, and all grafts were applied in combination with coronally advanced flap (CAF) surgery. Clinical and histological outcomes, including epithelial remnants, root coverage, keratinized tissue gain, surgical duration, and postoperative patient comfort, were assessed. The study seeks to identify a reliable, operator-independent method that minimizes epithelial remnants and improves clinical outcomes and patient experience.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Voluntary individuals aged between 18 and 80 years
* Systemically healthy
* Non-smokers
* Patients diagnosed with periodontal health following Phase I therapy, with reduced periodontium both clinically and radiographically
* Presence of Cairo RT I and RT II gingival recession defects involving maxillary and mandibular anterior and premolar teeth
* Presence of at least 1 mm of keratinized gingiva
* Individuals not using any medications that may affect periodontal tissue health or wound healing
* Absence of any pathology in the palatal mucosa that may interfere with the surgical procedure for connective tissue harvesting
Exclusion Criteria:
* Teeth with caries, non-carious cervical lesions, or restorations in the gingival recession area
* Teeth with endodontic pathology
* Pregnant or lactating women
* Patients with cardiac pacemakers
* Teeth where the cementoenamel junction cannot be clearly identified
* Individuals for whom the use of a radiofrequency device may pose a risk
* Use of antibiotics or immunosuppressive medications within the last 3 months
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.