This study is to evaluate the effectiveness of targeted Transcranial Electrical Stimulation with Temporal Interference (TES-TI) interventions to boost Non-Rapid Eye Movement (NREM) sleep, decrease seizures and promote emotional health in patients with epilepsy. Up to 24 participants (8 control participants for technical optimization prior to recruitment and 16 patients with epilepsy) will be enrolled and can expect to be on study for up to 24 months.
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NREM Sleep Slow-Wave Activity Measured by High-Density EEG (delta power)
Timeframe: measured during 8 overnight visits, data collected up to 24 months on study
Number of Seizures per week
Timeframe: data collected at 4 time points up to 24 months on study, 1 month and 3 month follow up after completion of 4 nights treatment and 1 month and 3 month follow up after completion 4 nights sham condition
Psychomotor Vigilance Task (PVT)
Timeframe: measured during 8 overnight visits, data collected up to 24 months on study
Restorative Sleep Questionnaire (REST-Q)
Timeframe: measured during 8 overnight visits, data collected up to 24 months on study
Stanford Sleepiness Scale (SSS)
Timeframe: measured during 8 overnight visits, data collected up to 24 months on study
Emotional Processing Task (Face Task): Percent Correct
Timeframe: measured during 8 overnight visits, data collected up to 24 months on study
Emotional Processing Task (Face Task): Percent Change in Reaction Time
Timeframe: measured during 8 overnight visits, data collected up to 24 months on study