Researchers are looking for new ways to treat 2 types of non-Hodgkin lymphoma (NHL) called follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). FL is a slow-growing type of NHL. DLBCL is a fast-growing type of NHL. NHL is a cancer in the lymphatic system that causes swollen lymph nodes. The lymphatic system is part of the immune system. In this study, researchers want to learn if MK-1045 can treat FL and DLBCL. MK-1045 is a study treatment that is an immunotherapy, which helps the immune system fight cancer. The goals of this study are to learn how safe MK-1045 is and if people tolerate it. Researchers also want to see if FL and DLBCL respond (the cancer gets smaller or goes away) to treatment.
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Number of Participants Who Experience an Adverse Event (AE)
Timeframe: Up to approximately 44 months
Number of Participants Who Discontinue Study Treatment Due to an AE
Timeframe: Up to approximately 12 months
Arms 2 and 3: Number of Participants Who Experience Dose Limiting Toxicity (DLT)
Timeframe: Up to approximately 28 Days
Arms 1 and 4: Objective Response Rate (ORR) per Lugano Response Criteria as assessed by Blinded Independent Central review (BICR)
Timeframe: Up to approximately 44 months
Arm 2: ORR per Lugano Response Criteria as assessed by Investigator
Timeframe: Up to approximately 44 months