The current study presents a unique opportunity to measure the immediate neural responses to brief, non-therapeutic transcranial low-intensity focused ultrasound (LIFU) pulses using intracranial electrodes. By recording time-locked signals in local and distant brain regions we can characterize circuit connectivity in real-time. We will use adult patients undergoing intracranial electrophysiological monitoring in an inpatient setting as our targeted population.
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Local spectral responses and temporally linked network activity, as measured by intracranial EEG
Timeframe: From enrollment to end of study is two weeks
Safety, as defined by the number and type of adverse events (AE) and change in clinical VAS scales
Timeframe: From enrollment to end of study is 2 weeks