RecruitingPhase 4

I.V Papavrine for Labor Induction in Term PROM

Israel110 participantsStarted 2025-10-22

Plain-language summary

This prospective randomized controlled trial aims to evaluate whether intravenous administration of papaverine 12 hours after term PROM reduces the interval from membrane rupture to delivery and improves maternal and neonatal outcomes. Researchers will compare drug papaverine to a placebo

Who can participate

Age range18 Years – 45 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * • Singleton pregnancy * Term gestation (37-42 weeks) * Term PROM prior to active labor * Duration of PROM \<12 hours at enrollment * Bishop score \<8 * Cephalic presentation * Viable fetus with reassuring fetal heart rate Exclusion Criteria: * • Multiple gestation * Previous cesarean delivery * Major fetal anomalies * Contraindication to vaginal delivery * Meconium-stained amniotic fluid * Suspected chorioamnionitis

What they're measuring

Time interval from rupture of membranes to delivery

Timeframe: up to 5 days from rupture of membranes

Trial details

NCT IDNCT07517796

SponsorWestern Galilee Hospital-Nahariya

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2027-10-22

Contact for this trial

Maya Frank Wolf, professor

• 972:50-7887800 mayaw@gmc.gov.il

View on ClinicalTrials.gov More Premature Rupture of Membranes trials