Study Population: Patients undergoing elective laparoscopic cholecystectomy under general anesthesia will be included. Study Design: This is an observational study. No interventions outside routine clinical practice will be applied. All procedures will be performed by experienced anesthesiologists according to standard institutional protocols. Data Collection Preoperative Data: The following variables will be recorded from anesthesia charts: Demographics: age, sex, height, weight, body mass index (BMI) Education level Smoking, alcohol, and substance use status Routine preoperative laboratory tests Clinical scores: Charlson Comorbidity Index (CCI) Beck Anxiety Scale ARISCAT Score STOP-BANG Score Montreal Cognitive Assessment (MoCA) ASA Physical Status Classification Intraoperative Data: Patients will be observed in two groups based on anesthesia technique: Desflurane + remifentanyl Total intravenous anesthesia (TIVA: propofol + remifentanyl) The following parameters will be recorded: Hemodynamic data: blood pressure, heart rate Oxygenation parameters: SpO₂, SpO₂/FiO₂ ratio Cerebral and depth monitoring: NIRS, BIS Respiratory mechanics Oxygen Saturation Index (OSI = \[Pmean × FiO₂\] / SpO₂) Mechanical ventilator parameters Time Points for Measurement: Before induction After induction After intubation Every 20 minutes intraoperatively After extubation Additional Intraoperative Variables: Duration of surgery and anesthesia Total anesthetic drug consumption: Desflurane and remifentanyl Propofol and remifentanyl (TIVA group) Intraoperative blood transfusion (yes/no) Total blood loss Urine output Recovery time Postoperative Follow-up ICU admission (planned or unplanned) Pain assessment using Numeric Rating Scale (NRS): PACU Postoperative 1st, 3rd, 6th, 12th, and 24th hours Postoperative Complications: Nausea and vomiting Hypotension Arrhythmia (bradycardia, tachycardia) Pulmonary edema Atelectasis Pneumonia Pneumothorax Pleural effusion Cognitive dysfunction Other Outcomes: Postoperative MoCA and Beck Anxiety Scale scores Length of hospital stay Length of ICU stay (if applicable) Mortality during follow-up
Age range
18 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Intraoperative cerebral oxygenation
Timeframe: During surgery