CompletedNot Applicable

Effect of Collagen Peptides on Skin Health: A Clinical Trial

China66 participantsStarted 2024-08-08

Plain-language summary

The goal of this clinical trial is to evaluate whether daily oral supplementation with 2.5 g of specific bioactive collagen peptides (SCP) can improve skin physiology in healthy adult women aged 35-55 years. The main questions it aims to answer are: Does SCP supplementation increase skin hydration and barrier function? Does SCP improve skin elasticity, firmness, and collagen content? Does SCP reduce the appearance of periorbital wrinkles and improve overall skin appearance? Researchers will compare SCP supplementation to a placebo (a look-alike substance containing no collagen peptides) to see if SCP supports skin structure and appearance over eight weeks. Participants will: Consume one sachet of SCP or placebo daily for eight weeks Attend three study visits at baseline, week 4, and week 8 for facial imaging, instrumental skin measurements, and expert assessments Have objective measures taken, including skin hydration, transepidermal water loss, elasticity, firmness, dermal collagen content, and 3D wrinkle morphology Complete subjective skin assessments rated by trained evaluators using a visual analogue scale Report any adverse events or intolerance reactions at each visit This study is designed to provide an integrated evaluation of multiple skin parameters, including barrier function, biomechanical properties, dermal matrix composition, and wrinkle characteristics, in a single trial. By combining objective and subjective measures, the study aims to generate robust and clinically interpretable evidence for the effects of oral collagen peptide supplementation on skin health.

Who can participate

Age range

35 Years – 55 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Fitzpatrick skin type III-IV * Presence of crow's feet wrinkles graded 2-4 * Presence of under-eye fine lines graded 2-5 * Generally in good health * Able to comply with study procedures and visit schedule Exclusion Criteria: * Use of systemic or topical anti-inflammatory medication, including corticosteroids, within the 4 weeks prior to baseline * Known hypersensitivity or allergy to any ingredient of the investigational products * Pregnancy, breastfeeding, or intention to become pregnant during the study period * History of relevant dermatological conditions: psoriasis, eczema, atopic dermatitis, or severe acne * Presence of birthmarks, hyperpigmentation, active inflammation, or other visible skin abnormalities in the test areas * Recent aesthetic procedures Use of anti-aging or topical treatments * Intake of nutritional supplements * Participation in other clinical studies within the past 2 months * Significant lifestyle or dietary changes during the study period * Excessive UV exposure * Systemic diseases, including heart, immune, vascular, liver, gallbladder, or kidney disorders * Known allergies to foods, cosmetics, skincare products, or topical medications * Any other condition that, in the investigator's opinion, would make the participant ineligible

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

stratum corneum hydration (SCH)

Timeframe: From enrollment to the end of treatment at 8 weeks

Trial details

NCT IDNCT07516756

SponsorCollagen Research Institute

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2024-10-04

View on ClinicalTrials.gov More Age-related Changes in Skin Appearance and Physiology trials