Active — Not RecruitingNot Applicable

Effect of Magnesium Supplementation on Sleep Quality and Cognitive Function in Saudi Adults

Saudi Arabia41 participantsStarted 2024-10-01

Plain-language summary

The goal of this clinical trial was to evaluate whether magnesium citrate supplementation improved sleep quality and cognitive function in healthy Saudi adults. It also assessed the effects of magnesium on selected blood markers. The main questions it aimed to answer were: Did magnesium supplementation improve sleep quality? Did magnesium supplementation improve cognitive function? Researchers compared participants who received magnesium citrate to a control group that did not receive any intervention to evaluate its effects. Participants: Took magnesium citrate (400 mg daily) for 90 days (two capsules: one in the afternoon and one 1-2 hours before bedtime) Visited Umm Al-Qura University twice (before and after the intervention) for: Sleep quality assessment Cognitive function assessment Blood sample collection to measure serum magnesium and HbA1c The control group did not receive any supplementation during the study period.

Who can participate

Age range

18 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 years and above * Poor Sleep Quality (\>5 PSQI score) * Living in Saudi Arabia Exclusion Criteria: * Children less than 18 years old * Good Sleep Quality (5 or less PSQI score) * Pregnant or breastfeeding * Current smoker * History of sleep disorder * History of cognitive impairment * Diagnosed with a disease (e.g. diabetes, hypertension, celiac, psychiatric disease) * Acute phase of diseases (e.g. cardiovascular) * History of head injury (e.g. accident) or neurological disorders (e.g. seizures)/neurodevelopment disorders * Use of prescribed medications within the past 3 months that may influence sleep * Current use of hormone therapy (e.g. thyroxine, insulin, growth hormone, contraceptives) * Use of dietary supplements within the previous 3 months (e.g. vitamin D, omega-3..etc) * Food allergies/intolerances (e.g. eggs, nuts, milk) * Excessive caffeine consumption (\>450 mg/day, more than 4 cups) * Shift worker or work schedules that cause irregular sleep patterns * History of travel to a different time zone in the previous month * Experiencing events that may cause severe stress for the previous 6 weeks from baseline (e.g. divorce or death or acute illness of a family member) * Has children between 0-2 years

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Sleep Quality from Baseline to 90 Days as Measured by PSQI Between Intervention and Control Groups

Timeframe: Participants were considered to have improved sleep quality if PSQI scores decreased from baseline to 90 days, especially if ≤5. Sleep outcomes were also compared between intervention and control groups after 90 days.

Change in Cognitive Function from Baseline to 90 Days as Measured by Trail Making Test (Parts A and B) Between Intervention and Control Group

Timeframe: From enrollment to the end of treatment at 90 days

Trial details

NCT IDNCT07515417

SponsorUmm Al-Qura University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-25

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