Catch up Growth Of Children After Closure Of Hemodinamically Significant Large VSD In Assuit University Children Hospital

Inclusion Criteria: * Children diagnosed with isolated large VSD meeting the following criteria: * Age from 1 month to 2 years old * Symptomatic patient with hemodynamically significant VSD by echocardiography who is candidate for closure. * Patients with pre-operative growth retardation * Patients undergoing successful closure Exclusion Criteria: * Associated complex heart lesions or cyanotic CHD (e.g., Tetralogy of Fallot). * Genetic syndromes affecting growth (e.g., Down syndrome , Turner syndrome) * Major extra-cardiac malformations or chronic systemic diseases (e.g., Renal failure,liver disease, metabolic disorder, Celiac disease). * Preoperative malnutrition unrelated to cardiac disease (e.g., malabsorption syndromes