Respiratory Function and S-index in Radiographic Axial Spondyloarthritis (NCT07515131) | Clinical Trial Compass
CompletedNot Applicable
Respiratory Function and S-index in Radiographic Axial Spondyloarthritis
Turkey (Türkiye)52 participantsStarted 2025-01-03
Plain-language summary
Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory disease that may lead to reduced chest expansion and impaired respiratory function due to thoracic involvement. While inspiratory muscle strength is commonly assessed using maximum inspiratory pressure (MIP), the S-index is a novel parameter reflecting dynamic inspiratory muscle strength and has not yet been investigated in this population.
This study aims to compare chest expansion, spirometric parameters, and S-index values between individuals with r-axSpA and healthy controls. Additionally, the relationships between these parameters and clinical indices (BASDAI, BASFI, and BASMI) will be evaluated in patients with r-axSpA. The study also aims to explore the potential role of the S-index in the assessment of pulmonary function in this patient group.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Willingness to participate in the study and provide informed consent
* Age ≥18 years
* Absence of any known chronic disease (for the healthy control group)
* Diagnosis of radiographic axial spondyloarthritis according to the Assessment of SpondyloArthritis international Society (ASAS) criteria and absence of any additional chronic disease (for the r-axSpA group)
Exclusion Criteria:
* Presence of known cardiopulmonary disease
* Presence of any rheumatologic disease other than radiographic axial spondyloarthritis (r-axSpA)
* Inability to cooperate with testing procedures
* Presence of chest wall or spinal deformities that may restrict lung capacity (e.g., pectus carinatum, pectus excavatum, scoliosis)
* Professional athletes
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.