CompletedNot Applicable

The Effect Of Low-Flow And Hıgh-Flow Anesthesıa On Intracranıal Pressure

Turkey (Türkiye)64 participantsStarted 2024-01-01

Plain-language summary

This prospective randomized study was conducted to evaluate the effects of low-flow and high-flow anesthesia on intracranial dynamics and cerebral oxygenation in patients undergoing laparoscopic hysterectomy in the Trendelenburg position. Intracranial pressure was assessed noninvasively using optic nerve sheath diameter (ONSD), and cerebral oxygenation was monitored using near-infrared spectroscopy (NIRS). Changes in these parameters were assessed under standardized pneumoperitoneum and positioning conditions, and comparisons between anesthesia flow groups were performed according to the predefined study protocol.

Who can participate

Age range18 Years – 75 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria * Female patients aged 18-75 years * Scheduled for elective laparoscopic hysterectomy * American Society of Anesthesiologists (ASA) physical status I-II * Ability to provide written informed consent Exclusion Criteria * Septicemia * Risk of malignant hyperthermia * Uncontrolled diabetes mellitus * Chronic alcohol use * Prolonged fasting * Body mass index (BMI) \> 40 kg/m² * Intracranial space-occupying lesions (e.g., tumors, metastases, abscesses, hematomas, aneurysms) * History of head trauma or cerebrovascular stroke within the preceding six months * Known heart failure * Diagnosis of glaucoma * Prior carotid surgery or carotid artery stenosis * ASA physical status ≥ III * Requirement for massive blood transfusion * Conversion from volume-controlled to pressure-controlled mechanical ventilation during surgery * Intraoperative conversion to open surgery * Patient refusal to participate

What they're measuring

Optic Nerve Sheath Diameter

Timeframe: 1-4 hour

Trial details

NCT IDNCT07514026

SponsorBursa City Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2024-12-01