Examining Olive Oil Extract on Knee Comfort and Function (NCT07514013) | Clinical Trial Compass
RecruitingNot Applicable
Examining Olive Oil Extract on Knee Comfort and Function
United States168 participantsStarted 2026-04
Plain-language summary
The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults?
The main procedures in the study include:
* Screening and informed consent
* Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks
* Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times
* Complete a Day 1 acute assessment and two simple functional movement tests at home as described below
* If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below.
* Collect saliva samples at home using a provided kit at designated timepoints
* Record any pain medications taken during the study or any side effects
Who can participate
Age range
40 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Participants must meet all of the following criteria to be eligible for participation:
* Adults aged 40 to 75 years
* Self-reported knee discomfort for at least 3 months
* Willing and able to take one study capsule daily for the duration of the study
* Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform
* Willing and able to wear a compatible activity-tracking device throughout the study
* Willing and able to collect saliva samples at home using a provided kit, if applicable
* Able to read and understand English
* Willing to provide informed consent electronically
Exclusion Criteria:
Participants will be excluded if any of the following apply:
* Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee
* Any current or prior diagnosis from a licensed medical provider of knee disease
* Knee surgery or significant knee injury within the past 6 months
* Planned knee surgery during the study period
* Known allergy or sensitivity to olive-derived products or any component of the study product
* Current use of investigational drugs or participation in another research study during the study period
* Any medical condition or circumstance that, in the opinion of the investigator, would make participation unsafe or interfere with study participation or data quality
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Knee pain (KOOS Pain subscale)
Timeframe: After 0, 1, 2, 3, 4, 5, and 6 weeks of supplementation.