This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with mild cognitive impairment (MCI), addressing the inconsistent results of generic brain stimulation protocols. By integrating artificial intelligence (AI)-derived insights with real-time data, the study aims to customize transcranial electrical stimulation (tES) parameters, including electrode placement, intensity, and frequency to target the specific brain regions responsible for abnormal signaling in each participant. Over the intervention period paired with computerized cognitive training, the project will evaluate improvements in learning, memory, and functional connectivity, while simultaneously identifying clinical and physiological predictors to determine the viability of transitioning this low-cost, non-invasive technology into a remotely supervised, home-based therapy setting. The study duration will be a total of 6-8 weeks.
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Change in auditory recall accuracy based on the sum of words recalled in Trials 1-5 of semantically related - trained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention
Change in auditory delayed recall accuracy of semantically related - trained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention
Change in auditory recall accuracy based on the sum of words recalled in Trials 1-5 of semantically unrelated - trained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention
Change in auditory delayed recall accuracy of semantically unrelated - trained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention
Change in auditory recall accuracy based the sum of words recalled in Trials 1-5 of semantically related - untrained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention
Change in auditory delayed recall accuracy of semantically related - untrained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention
Change in auditory recall accuracy based on the sum of words recalled in Trials 1-5 of semantically unrelated - untrained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention
Change in auditory delayed recall accuracy of semantically unrelated - untrained word-lists
Timeframe: Before intervention, immediately after intervention and 1 month post intervention