CompletedNot Applicable

Hyperoxia vs Normoxia During Cardiopulmonary Bypass

Italy104 participantsStarted 2025-07-01

Plain-language summary

This single-center randomized controlled pilot trial evaluates the effects of intraoperative hyperoxia compared with normoxia during cardiopulmonary bypass (CPB) in adult patients undergoing elective cardiac surgery. The primary aim is to assess the impact on postoperative renal function. Secondary outcomes include inflammatory markers, cardiovascular and pulmonary complications, resource utilization, and short-term mortality.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adult patients (\>18 years old) * need for elective cardiac surgery requiring CPB (i.e., isolated valve repair/replacement, coronary artery bypass grafting, or ascending aorta surgery) * Time frame from July 1st to September 15th 2025 Exclusion Criteria: * refusal of consent, * pregnancy, * previous Intensive Care Unit (ICU) admission, * history of cardiac surgery requiring CPB, * signs of preoperative cardiogenic shock (defined as requiring inotropic support, intra-aortic balloon pump, or other mechanical circulatory assistance), * intraoperative need for circulatory arrest.

What they're measuring

Number of of kidney failure in adult patients undergoing to elective cardiac surgery required CPB

Timeframe: At 24 hours after surgery

Trial details

NCT IDNCT07510672

SponsorUniversity of Padova

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09-15

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