CompletedNot Applicable

Efficacy of Human UC-MSC-derived Exosomes and BM-MSC-derived Exosomes for Atrophic Acne Scar

Vietnam22 participantsStarted 2025-01-17

Plain-language summary

The goal of this clinical trial is to learn if exosomes from human umbilical cord and bone marrow can improve atrophic acne scars when used after fractional CO₂ laser treatment in adults. The main questions it aims to answer are: * Do exosomes improve acne scars more than standard treatment alone? * Are exosomes safe when used after laser treatment? Researchers will compare one side of the face treated with exosomes to the other side treated with a control solution (hyaluronic acid) to see if exosomes improve scar appearance and skin texture. Participants will: * Receive two sessions of fractional CO₂ laser treatment, 4 weeks apart * Have exosomes applied to one side of the face and a control solution applied to the other side after each treatment * Continue applying the assigned solution at home for 2 days after each session * Attend follow-up visits to assess scar improvement, skin texture, healing time, and side effects Researchers will measure changes in acne scars using clinical scoring systems, skin imaging, and patient satisfaction. Safety will also be monitored by recording any side effects such as redness, swelling, or acne flare. This study may help determine whether exosomes can improve the results of laser treatment for acne scars without increasing side effects

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged ≥18 years * Presence of bilateral atrophic acne scars on the face * Eligible for ablative fractional CO₂ laser treatment Exclusion Criteria: * \- Pregnancy or breastfeeding * History of keloid or hypertrophic scarring * Active acne inflammation or facial infection * Use of oral isotretinoin within the past 6 months * Recent facial procedures within the past 6 months, including ablative laser, radiofrequency microneedling, dermabrasion, or medium-to-deep chemical peel * Use of systemic corticosteroids or non-steroidal anti-inflammatory drugs affecting wound healing

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Percentage improvement in ECCA score

Timeframe: Baseline to 8 weeks

Trial details

NCT IDNCT07510295

SponsorNgô Anh Tuấn

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-07

View on ClinicalTrials.gov More Atrophic Acne Scars trials