Effect Of Electroacupuncture With Local Anesthesia On Pain And Stress During Impacted Lower Third… (NCT07509294) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect Of Electroacupuncture With Local Anesthesia On Pain And Stress During Impacted Lower Third Molar Surgery
Croatia60 participantsStarted 2026-04-20
Plain-language summary
This randomized controlled trial investigates the effect of electroacupuncture as an adjunct to local anesthesia on perioperative pain and stress during ambulatory surgical extraction of impacted lower third molars. Participants will be randomized into three groups: electroacupuncture, sham acupuncture, and control. Pain intensity and perceived stress will be assessed using validated scales, while biological stress and nociceptive markers (salivary cortisol, alpha-amylase, and substance P), as well as hemodynamic parameters (blood pressure and heart rate), will be measured. The study aims to provide an integrated evaluation of the effects of electroacupuncture on subjective, biological, and physiological indicators of perioperative response in oral surgery.
Who can participate
Age range
25 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 25-35 years
* ASA physical status I-II
* Indication for ambulatory surgical extraction of an impacted lower third molar
* Ability to understand the study procedures and provide written informed consent
* Willingness to comply with study procedures, including saliva sampling protocol
* Ability to abstain from food, beverages, and oral hygiene procedures for at least 1 hour prior to saliva sampling
Exclusion Criteria:
* Pregnancy
* Epilepsy
* Presence of a pacemaker or other active electronic implant
* Coagulation disorders
* Active infection at the site of acupuncture
* Systemic inflammatory diseases
* Oral inflammatory conditions (e.g., gingivitis or periodontitis)
* Hyposalivation
* Chronic opioid use
* Psychiatric conditions that may affect pain or stress assessment
* Use of nonsteroidal anti-inflammatory drugs, corticosteroids, or antibiotics within 7 days prior to the procedure
* Menstruation at the time of saliva sampling
* Inability or unwillingness to comply with study procedures
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Perioperative Pain Intensity
Timeframe: Baseline and 30 minutes after surgical extraction