Effect Of Electroacupuncture With Local Anesthesia On Pain And Stress During Impacted Lower Third… (NCT07509294) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect Of Electroacupuncture With Local Anesthesia On Pain And Stress During Impacted Lower Third Molar Surgery
Croatia60 participantsStarted 2026-04-20
Plain-language summary
This randomized controlled trial investigates the effect of electroacupuncture as an adjunct to local anesthesia on perioperative pain and stress during ambulatory surgical extraction of impacted lower third molars. Participants will be randomized into three groups: electroacupuncture, sham acupuncture, and control. Pain intensity and perceived stress will be assessed using validated scales, while biological stress and nociceptive markers (salivary cortisol, alpha-amylase, and substance P), as well as hemodynamic parameters (blood pressure and heart rate), will be measured. The study aims to provide an integrated evaluation of the effects of electroacupuncture on subjective, biological, and physiological indicators of perioperative response in oral surgery.
Who can participate
Age range25 Years – 35 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 25-35 years
* ASA physical status I-II
* Indication for ambulatory surgical extraction of an impacted lower third molar
* Ability to understand the study procedures and provide written informed consent
* Willingness to comply with study procedures, including saliva sampling protocol
* Ability to abstain from food, beverages, and oral hygiene procedures for at least 1 hour prior to saliva sampling
Exclusion Criteria:
* Pregnancy
* Epilepsy
* Presence of a pacemaker or other active electronic implant
* Coagulation disorders
* Active infection at the site of acupuncture
* Systemic inflammatory diseases
* Oral inflammatory conditions (e.g., gingivitis or periodontitis)
* Hyposalivation
* Chronic opioid use
* Psychiatric conditions that may affect pain or stress assessment
* Use of nonsteroidal anti-inflammatory drugs, corticosteroids, or antibiotics within 7 days prior to the procedure
* Menstruation at the time of saliva sampling
* Inability or unwillingness to comply with study procedures
What they're measuring
1
Perioperative Pain Intensity
Timeframe: Baseline and 30 minutes after surgical extraction