Not Yet RecruitingNot Applicable

Low Versus Standard Volume EXORA Block in Laparoscopic Cholecystectomy

Egypt96 participantsStarted 2026-04-10

Plain-language summary

The original EXORA block used high local anesthetic volume (50 mL total), raising concerns about local anesthetic systemic toxicity (LAST). In such a bilaterally administered regional technique, evaluating the efficacy of a reduced-volume approach is warranted to maximize patient safety.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I or II. * Scheduled for elective laparoscopic cholecystectomy under general anesthesia. Exclusion Criteria: * • Patient refusal to participate. * Obese patients with a body mass index of more than 35 kg/m2. * Known cognitive impairment or use of psychiatric drugs * Known allergy to local anesthetics * Infection at the needle insertion site. * Coagulopathy, or bleeding disorders. * Pregnancy * History of chronic pain or chronic opioid use. * Previous major upper abdominal surgery (which alters the fascial planes and anatomy). Criteria for Withdrawal from Study Analysis (Drop-outs): * Conversion to open cholecystectomy during surgery. * Failed EXORA block

What they're measuring

Dynamic numerical rating scale (NRS) score at 4 hours postoperatively.

Timeframe: 4 hours after surgery

Trial details

NCT IDNCT07507799

SponsorFayoum University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-01

Contact for this trial

Mohammed R Gomaa, Bch

1097830069 mr147@fayoum.edu.eg

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