RecruitingNot Applicable

Beverage Hydration Index of Different Solutions

United States30 participantsStarted 2026-02-23

Plain-language summary

In this study, the impact of two electrolyte hydration stick products (Hydramin containing an electrolyte/amino acid formulation and an identical electrolyte product with the amino-acids replaced with carbohydrate, dextrose) dissolved in 1 liter of water will be assessed and compared to a control (1 liter Smart Water). It is hypothesized that the addition of amino acids and glycine should improve the Beverage Hydration Index above water alone and perform comparably to the carbohydrate rich solution. This study will focus on general population (not athletes) and follow very similar approaches used in previous studies within the Center for Nutraceutical and Dietary Supplements Research, with the addition of blood glucose testing and body water measurements. Hydration will be assessed via fluid balance (the difference between the amount of water consumed and passed as urine) and calculations of beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water)as well as time in positive fluid balance, and specific gravity, and sodium and potassium in urine. Blood glucose before and following consumption using finger pricks and a glucometer will also be assessed.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* Be age 18 years or older * male or female * have a body mass index (BMI)between 18.5-35 kg/m2 (not morbidly obese) * Be engaged in moderate physical activity, defined as ≤5 hours/week of aerobic exercise * Not have a history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder (reviewed by Nurse practitioner) * Not have other conditions that are likely to alter fluid balance or be negatively affected by changing electrolyte levels/hydration status (as determined by Nurse practitioner) * Not be consuming any medication which may alter fluid retention/electrolyte levels such as Selective Serotonin Reuptake Inhibitors, sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium. (Medications will be reviewed by Nurse practitioner) * Not consume nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening. * Follow the lifestyle and dietary restrictions before study visits (excluding screening/consenting visit) including before each visit avoiding strenuous activity for 24 hours prior, refrain from caffeine for 12 hours and alcohol for 24 hours, consume the standardized diet and maintain similar activity levels for 24 hours prior, consume 2.5 liters for men or 2.…

What they're measuring

Beverage Hydration Index

Timeframe: 0 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 60 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 120 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 180 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 240 minutes after beverage consumption

Net Fluid Balance

Timeframe: 0 minutes after beverage consumption

Net Fluid Balance

Timeframe: 60 minutes after beverage consumption

Net Fluid Balance

Timeframe: 120 minutes after beverage consumption

Trial details

NCT IDNCT07507344

SponsorUniversity of Memphis

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30

Contact for this trial

Jacquelyn Pence, PhD

901-678-1547 jpence1@memphis.edu

View on ClinicalTrials.gov More Hydration trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Beverage Hydration Index

Timeframe: 0 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 60 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 120 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 180 minutes after beverage consumption

Beverage Hydration Index

Timeframe: 240 minutes after beverage consumption

Net Fluid Balance

Timeframe: 0 minutes after beverage consumption

Net Fluid Balance

Timeframe: 60 minutes after beverage consumption

Net Fluid Balance

Timeframe: 120 minutes after beverage consumption