Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability
China40 participantsStarted 2026-03-20
Plain-language summary
This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio \<= 200 mmHg)
* Under continuous sedation with or without paralysis
Exclusion Criteria:
* Age \<18 years
* Bronchopleural fistula
* Pure COPD exacerbation
* Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
* Hemodynamic instability (Systolic BP \< 75 mmHg or MAP \< 60 mmHg despite vasopressors and/or heart rate \< 55 bpm)
* Contraindications to mobilization (e.g., intracranial hypertension, spinal cord injury)
* Intra-abdominal hypotension (IAP≥12mmHg)
* Pregnancy
* Attending physician deems the transient application of high airway pressures to be unsafe