The goal of this observational study is to examine how different physiological markers change over a two-day period after long-duration whole-body cold-water immersion in healthy young men and women. Specifically, the study aims to address the following questions: * How do kynurenine pathway metabolites change after cold exposure? * How do stress markers change after cold exposure? * How do cytokine levels change after cold exposure? * How do white blood cells count and distribution change after cold exposure?
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Change in plasma metabolites of the kynurenine pathway (μm)
Timeframe: 2 days
Body temperature (°C)
Timeframe: 1 day
Cold strain index
Timeframe: 1 day
Free cortisol concentration (µg/dl)
Timeframe: 2 days
Cytokines concentrations (pg/ml)
Timeframe: 2 days
Total cortisol concentration (nmol/l)
Timeframe: 2 days
Catecholamines concentration (ng/ml)
Timeframe: 2 days
Complete blood count (10^9/L)
Timeframe: 2 days
Glucose (mmol/l)
Timeframe: 2 days