Effect of the Combination of Nitrate and Caffeine on Critical Power In Trained Male Cyclists (NCT07501806) | Clinical Trial Compass
CompletedNot Applicable
Effect of the Combination of Nitrate and Caffeine on Critical Power In Trained Male Cyclists
United States15 participantsStarted 2020-11-17
Plain-language summary
This study is investigating the independent and combined effects of acute dietary nitrate and caffeine supplementation on performance during a 3-minute all-out cycling test in trained male cyclists. In a randomized, double-blind, placebo-controlled, crossover design, participants will complete four experimental conditions: nitrate, caffeine, nitrate plus caffeine, and placebo. Primary outcomes include end power (EP) and work done above end power (WEP), surrogate measures of critical power and W'. The study aims to determine whether combined supplementation provides additive benefits for severe-intensity exercise performance.
Who can participate
Age range
18 Years – 40 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Males between the ages of 18 and 40 years of age
* All participants must be trained cyclists, having participated in structured cycling training consisting of at least 2-3 sessions per week for at least 30-60 min each session during the past 12 months.
* All participants must possess a relative max power output (Wmax) of 4.0 W/kg or greater OR a maximal oxygen consumption (VO2max) of 50 ml/kg/min.
* All participants must be healthy and free of any disease as determined through the completion of a medical history questionnaire.
* Body mass index (BMI) between 18.5 - 30 kg/m\^2 OR bodyfat percentage \<30%
Exclusion Criteria:
* All females
* Males who are younger than 18 years and older than 40 years of age
* Individuals who have a VO2max below 50 ml/kg/min and a relative Wmax below 4.0 W/kg
* Individuals who fail to meet the minimum training requirements of 2-3 sessions per week of structured cycling training for at least 30-60 min per session during the past 12 months.
* Any individual currently diagnosed with or being treated for any cardiovascular, renal, pulmonary, orthopedic, immunological, psychological or musculoskeletal disorder.
* Any individual who is currently supplementing with a known or purported ergogenic aid (nitrates, caffeine, beta-alanine, bicarbonate, creative, Cordyceps) will be required to refrain from their use for 30 days before beginning the study.
* Individuals who regularly smoke or have quit smoking within the last 6 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
End Power
Timeframe: Assessed during a single 3-minute all-out cycling test, approximately 3 hours following supplementation
2
Work Above End Power
Timeframe: Assessed during a single 3-minute all-out cycling test, approximately 3 hours following supplementation