Study of the Role of Top-down Processes in Neuronal Reorganization and Recovery From Sensory Loss… (NCT07500909) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Study of the Role of Top-down Processes in Neuronal Reorganization and Recovery From Sensory Loss: an Exploratory Behavioral and Electroencephalographic Study in Cochlear-supported Deaf Patients
90 participantsStarted 2026-03-01
Plain-language summary
This study posits that central top-down processes (attention, inhibition), marked by alpha oscillations in EEG, play a key role. Understanding the evolution of these neuronal signatures and their link to pre-implantation visual dependence could allow the identification of biomarkers predictive of the success of auditory rehabilitation.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
For cochlear implant patients:
* Adult patients
* Profound bilateral hearing loss requiring a first cochlear implant
* Normal cochlear anatomy (confirmed by preoperative imaging)
* Full insertion of the cochlear electrode array planned
* Acceptance of the protocol and signing of the informed consent form
* Enrollment in a social security or equivalent plan
For young patients with normal hearing:
* Adult patients aged 18 to 40
* Normal and symmetrical hearing
* Acceptance of the protocol and signature of the informed consent form
* Affiliation with a social security scheme or equivalent
For older patients with normal hearing:
* Patients over 50 years of age, matched by gender and age (+/- 2 years) with the cochlear implant patient group
* Normal and symmetrical hearing, with hearing thresholds \< 20 dB HL at 2 kHz and \< 40 dB HL at 4 kHz
* Acceptance of the protocol and signature of the informed consent form
* Affiliation with a social security scheme or equivalent
For experienced cochlear implant recipients:
* Adult patients.
* Unilateral cochlear implant activated for 1 year or more.
* Disyllabic word recognition score at 60 dB in free field of 70% or higher.
* Acceptance of the protocol and signature of the informed consent form.
* Affiliation with a social security plan or equivalent.
For severely deaf patients fitted with hearing aids:
* Adult patients.
* Severe bilateral hearing loss.
* Rehabilitation with one or two optimally fitted hearin…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.