The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process could prevent or delay multiple diseases, enhancing healthspan. Fucoidan, a sulfated polysaccharide from brown macroalgae, is a safe dietary supplement with Sirtuin-6 (SIRT6) activating properties, which are linked to longevity. Clinical studies have shown that it reduces inflammatory markers associated with biological aging and frailty and influences DNA methylation in vitro and in vivo; however, its effects on human DNA methylation remain unknown.
Who can participate
Age range50 Years – 80 Years
SexMALE
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Inclusion criteria
✓. 50-80 years males;
✓. Resident of Singapore (citizenship or permanent residency is not required);
✓. Prefrail according to Fried frailty phenotype score;
✓. English-literate who can understand, read and write in English;
✓. Individuals without severe cognitive impairment, as determined by PI judgment;
✓. Apparently healthy and non-smokers having not more than 2 of the following conditions. If the conditions are present they have to be stable:
Exclusion criteria
✕. Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease);
✕. Current cancer or non-stable chronic obstructive pulmonary disease (COPD);
✕. Use of anticoagulant medication;
✕
What they're measuring
1
Change in blood DNA methylation status, years
Timeframe: from baseline to end of intervention (6 months)
✕. Having hairiness, moles, tattoos, scars, irritated skin, etc. on the face which could influence the investigation;
✕. Having used within the 3 past weeks for more than 3 consecutive days any systemic or topical drugs related to antibiotics or having planned to use these treatments during the study;
✕. Having a positive serology for HIV, HEPATITIS B, HEPATITIS C\*
✕. Subject with any contra-indication for skin microbiopsies: