Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Study

Inclusion Criteria: * 1\) Patients age at least 18 years old. 2) Patient with partial edentulous teeth bounded areas that need dental implant for teeth replacement. 3\) Adequate bone volume for implant placement (at least 5 mm width - 10 mm height). 4\) Ability to tolerate conventional surgical and restorative procedures. 5) Patients who are willing to comply the study and give their consent. Exclusion Criteria: \- 1) Active infection or inflammation in the implant zone. 2) Presence of any uncontrolled systemic diseases. 3) Patient with history of chemotherapy or radiotherapy. 4) Patient had undergone bone grafting and soft tissue procedures prior to implant surgery. 5\) Patient had undergone tooth extraction at the implant site less than 6 months prior to implant surgery.