Not Yet RecruitingNot Applicable

Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.

50 participantsStarted 2026-03-22

Plain-language summary

To compare the effect of 1% melatonin gel versus calcium hydroxide as intra canal medication in necrotic mandibular premolars on: * Intensity of postoperative pain. * Bacterial load reduction. * Periapical (MMP-9) level.

Who can participate

Age range21 Years – 50 Years

SexALL

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Inclusion criteria

✓. Age between 18-50 years old.
✓. Males and females.
✓. Healthy patients categorized as I or II according to The American Society of Anesthesiologists. (ASA I or II), with no underlying allergies.
✓. Single-rooted mandibular premolar teeth, having single root canal: diagnosed clinically with pulp necrosis.
✓. Patients accepting to participate in the trial.
✓. Patients who can understand pain scale (Appendix I) and can sign the informed consent (Appendix II).

Exclusion criteria

✕. Medically compromised patients having significant systemic disorders (ASA III or IV).
✕. Pregnant females.
✕. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.
✕. Teeth with multiple canals.
✕. Teeth that show association with acute periapical abscess or swelling.
✕. Teeth with vital pulp.
✕. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam.

What they're measuring

Intensity of postoperative pain

Timeframe: up to 48 hours

Trial details

NCT IDNCT07495605

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Alaa Ibrahim Mekhimar

00201101700576 alaa.ibrahim@dentistry.cu.edu.eg

View on ClinicalTrials.gov More Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp trials